Routes Of Drug Administration Their Advantages And Disadvantages Pdf

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It refers to the right path or the required route through which a drug has to be administered into the body to obtain maximum benefit.

Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. For all species, many different routes are available for administration of substances.

Route of administration

Introduction to Basics of Pharmacology and Toxicology pp Cite as. It becomes more than essential for a clinical pharmacologist to understand the various principles and modes of drug administration, since these are clinically relevant in therapeutics, and helps in avoiding any potential harm to patients receiving these drugs.

While there are several principles of drug administration, the five important ones are: the right patient, the right drug, the right dose, the right time and the right route of administration. Modes or routes of drug administration vary from the widely followed oral route to parenteral and inhalational routes.

There also exist certain specialized routes and modes of drug delivery, like the liposomal delivery, prodrug delivery and others. Each of these routes of administration has its own pros and cons, which have to be weighed against each other before choosing the same. This chapter deals about the key principles and routes or modes of drug administration. Skip to main content. This service is more advanced with JavaScript available.

Advertisement Hide. Principles and Modes of Drug Administration. Chapter First Online: 17 November This is a preview of subscription content, log in to check access. Wu K A new classification of prodrugs: regulatory perspectives. Sanofi India Ltd. Chennai India. Personalised recommendations. Cite chapter How to cite? ENW EndNote.

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Parenteral Route of Drug Administration: Advantages and Disadvantages

Introduction to Basics of Pharmacology and Toxicology pp Cite as. It becomes more than essential for a clinical pharmacologist to understand the various principles and modes of drug administration, since these are clinically relevant in therapeutics, and helps in avoiding any potential harm to patients receiving these drugs. While there are several principles of drug administration, the five important ones are: the right patient, the right drug, the right dose, the right time and the right route of administration. Modes or routes of drug administration vary from the widely followed oral route to parenteral and inhalational routes. There also exist certain specialized routes and modes of drug delivery, like the liposomal delivery, prodrug delivery and others. Each of these routes of administration has its own pros and cons, which have to be weighed against each other before choosing the same.

The way in which medicines are administered will to some extent influence their clinical benefit and whether patients experience any adverse effects. For example, if IV furosemide is administered too quickly, it can cause deafness, while oral penicillin V will not be well absorbed if given with food. Route of administration and formulation — tablet, capsule, liquid — can influence the bioavailability of a drug. Bioavailability is the proportion of a drug that reaches the systemic circulation and is therefore available for distribution to the intended site of action. Some drugs that are particularly well absorbed by the gastrointestinal mucosa may have bio-availability comparable with that of an IV dose, for example the antibiotic ciprofloxacin. However, most drugs do not have this level of availability by the oral route so the dose given orally is usually higher than that given parenterally.


Most of the drugs can be administered by different routes. The absorption pattern, advantages, and disadvantages of the most common routes of administration.


Drug Administration

A route of administration in pharmacology and toxicology is the path by which a drug , fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action is.

Alternative routes of drug administration - Advantages and disadvantages (subject review)

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Given by injection into a vein intravenously, IV , into a muscle intramuscularly, IM , into the space around the spinal cord intrathecally , or beneath the skin subcutaneously, sc. Breathed into the lungs, usually through the mouth by inhalation or mouth and nose by nebulization. See also Introduction to Administration and Kinetics of Drugs. Many drugs can be administered orally as liquids, capsules, tablets, or chewable tablets. Because the oral route is the most convenient and usually the safest and least expensive, it is the one most often used.

3 Response
  1. Gabrielle R.

    might expected from their administration be able to describe the biopharmaceutically relevant advantages and disadvantages of various routes.

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